Comparison of aerosol ipratropium bromide and salbutamol in chronic bronchitis and asthma.
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چکیده
منابع مشابه
The effect of aerosol ipratropium bromide and salbutamol on exercise tolerance in chronic bronchitis.
In a double-blind placebo controlled trial in 24 patients fulfilling the MRC criteria for chronic bronchitis, ipratropium bromide 40 microgram and salbutamol 200 microgram produced similar and significant (P less than 0.001) increases in forced expiratory volume in one second (FEV1) and forced vital capacity (FVC). A greater increase in FEV1 and FVC was seen when both drugs were used together, ...
متن کاملEffects of allergy and age on responses to salbutamol and ipratropium bromide in moderate asthma and chronic bronchitis.
The bronchodilating responses to 400 micrograms salbutamol and 80 micrograms ipratropium bromide were studied in 188 patients with chronic bronchitis (n = 113) or asthma (n = 75) and mild to moderate airflow obstruction (forced expiratory volume in one second (FEV1) above 50% but below 2 SD of predicted value) in a crossover study on two days a week apart. Both the patients with asthma and the ...
متن کاملEffect of salbutamol and ipratropium bromide on airway calibre and bronchial reactivity in asthma and chronic bronchitis.
Bronchial reactivity to agonists such as histamine is seen in both chronic bronchitis and asthma, two conditions with different pathological changes in the airways. Salbutamol, when given acutely, reduces bronchial reactivity in patients with asthma, but the mechanism has not been clarified. To determine whether the effect of salbutamol depends on the pathological changes underlying the increas...
متن کاملIpratropium bromide: a review of its pharmacological properties and therapeutic efficacy in asthma and chronic bronchitis.
Ipratropium bromide is an anticholinergc bronchodilator administered by inhalation. Although producing bronchodilation in most patients with obstructive airways disease, it is somewhat less effective than beta 2-adrenoceptor agonist drugs such as salbutamol or fenoterol in patients with asthma, but is at least as effective as these agents in bronchitis. As with the beta 2-adrenoceptor agonists,...
متن کاملCumulative dose-response curves for assessing combined effects of salbutamol and ipratropium bromide in chronic asthma.
We investigated whether salbutamol (S) and ipratropium bromide (IB) exerted a true additive bronchodilator effect in asthma. In fifteen selected chronic asthmatics, individual cumulative dose-response curves to S and IB were performed on two separate days (linear regression of bronchodilator response (delta FEV1) between 20 and 80% of maximal response, versus log dose), and the dose of S equipo...
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ژورنال
عنوان ژورنال: BMJ
سال: 1975
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.1.5955.430